A staged protocol for rebuilding the gut terrain — backed by 30 years of clinical research. Four phases. One sequence. The order is the protocol.
You can't reseed a gut that hasn't been primed. You can't fortify what hasn't been seeded. And nothing holds without a maintenance rhythm. The MEND Method is the order Progurt's clinical work converged on over thirty years — and the order each protocol bundle follows.
The four phases below walk through what each one does, what lives in it, and where it sits in the protocol. The order is the protocol.
Prepare the gut terrain so what comes next can actually take hold.
Before any reseeding makes sense, the gut needs to be receptive. Minerals and fluids set the environment for everything else — pH, motility, the mucus layer that beneficial bacteria adhere to. Skip this step and the next one has nothing to land on.
Mineralise is short by design. Seven days of pH buffering and chloride loading. The terrain is primed, then the protocol moves on.
More on what mineralise does, how long it runs, and what it feels like when it's working.
Read the Mineralise deep-dive →Reseed the beneficial bacteria the gut needs but doesn't have.
Once the terrain is primed, Establish brings in the populations the gut is missing. Progurt uses Human Probiotic Isolates™ — strains originally isolated from healthy human gut microbiomes, not foreign or soil-derived strains.
Establish runs across Days 7–14. Seven days gives the strains time to colonise the terrain you just prepared. By the end of Establish, the ecosystem is in place — but it isn't yet fed.
Five Probiotic Sachets — 1 trillion CFU of Human Probiotic Isolates™ each — plus pH support, on a monthly rhythm.
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Probiotic Sachets
The Establishers — 1 Trillion CFU HPI™
Probiotic Yogurt (HPI)
The Establishers — live culture format
More on what establish does, how long it runs, and what it feels like when it's working.
Read the Establish deep-dive →Four questions — where you are, what you've tried, what's the goal — and we'll route you to the phase that fits where you are.
Feed and fortify the ecosystem so it can hold.
A populated gut is not yet a resilient one. Nourish feeds the established strains with prebiotic fibre, fortifies the gut barrier, and supports the digestive flow that keeps the ecosystem moving.
This is the phase most people skip — and the phase most responsible for whether the gains from Establish are kept past week six.
The rhythm Nourish builds on — sachets, pH, and Chloride monthly. Add the Nourish trio alongside.
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Prebiotic Syrup
Microbiome Nourisher
Immuno Protein
Barrier + Immune Defender
Enzymes
Flow Optimiser
More on what nourish does, how long it runs, and what it feels like when it's working.
Read the Nourish deep-dive →Maintain what you built. Long-term.
Defend is the maintenance phase — and the phase most customers stay in once they reach it. A monthly rhythm of probiotic refills, the Nourish stack, and the Incubator for at-home yogurt culture.
Defend isn't an end-point. It's the running protocol of someone whose gut works.
The monthly subscription: sachets, pH, and Chloride every 30 days — the box you stop thinking about.
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Incubator
Yogurt Incubator — at-home culture
Probiotic Sachets (refill)
Ongoing Establish dose
Prebiotic Syrup
Nourish continues — with Immuno Protein & Enzymes
More on what defend does, how long it runs, and what it feels like when it's working.
Read the Defend deep-dive →Most customers begin at Mineralise or Establish. A few jump in at Nourish, post-reset. None of the entry points are wrong — they're just different starting points in the same sequence.
Welcome offer
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Welcome offer
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