Fertility & Hormones
PCOS, irregular cycles, conception support, perimenopause — the gut microbiome plays a significant role in hormone metabolism and regulation. If hormonal interventions alone haven't worked, there's often a reason.
Your gut microbiome contains what researchers call the 'estrobolome' — a collection of bacteria that metabolise and regulate oestrogen and other hormones. When this bacterial population is disrupted, hormonal balance often follows.
Whether you're navigating PCOS, preparing for conception, or managing hormonal transitions, gut health plays a foundational role that's often overlooked.
Do you experience...
If several of these resonate, your gut-hormone connection may be involved.
- Irregular menstrual cycles
- PCOS or PCOS-like symptoms
- Difficulty conceiving
- PMS or PMDD symptoms
- Hormonal acne or skin changes
- Mood changes tied to your cycle
Why Progurt Works When Others Haven't
Three problems with addressing hormones directly — and how MEND addresses each one.
Hormone Replacement
Adding hormones externally doesn't address why your body isn't metabolising them properly. If your estrobolome is disrupted, you're treating downstream.
Hormone Metabolism Support
MEND supports the bacterial populations that properly metabolise and regulate hormones. Address the processing, not just the levels.
Fertility Treatments Alone
IVF success rates correlate with vaginal microbiome composition — which is influenced by gut microbiome. Many fertility protocols miss this foundation.
Foundation Optimisation
Supporting gut health creates better conditions for conception. Many practitioners now recommend microbiome support alongside fertility treatments.
Symptom Cycling
Addressing symptoms as they arise — a different supplement for each phase — doesn't create lasting hormonal resilience.
Long-term Balance
A healthy estrobolome supports consistent hormone metabolism throughout your cycle. Build the foundation, not just manage the peaks and valleys.
Common Misconception
"Hormone problems need hormone solutions" — While hormonal interventions have their place, the gut's role in hormone metabolism means that microbiome support is often foundational.
Your Recommended Starting Point
Based on hormonal and fertility concerns, we recommend starting with Gentle Reset.
Why this bundle:
- Supports the estrobolome and hormone metabolism
- Human-origin bacteria for better gut-hormone communication
- Safe and appropriate for fertility preparation
- Foundation for hormonal resilience
Frequently Asked Questions
Is Progurt safe during conception attempts?
Yes. Progurt contains beneficial bacteria that support overall health. Many practitioners recommend optimising the microbiome before and during conception. As always, discuss any supplement with your healthcare provider.
Can this help with PCOS?
PCOS is a complex condition involving gut bacteria, inflammation, and hormones. While we can't make treatment claims, research supports the role of microbiome health in PCOS management, and many with PCOS find gut support helpful.
How long before I might notice cycle changes?
Menstrual cycles operate on monthly rhythms, so meaningful changes typically take 2-3 cycles to observe. Some people notice subtle shifts sooner, while deeper hormonal patterns take longer to shift.
Can I use this alongside hormone treatments?
In most cases, yes. Gut support is complementary to hormonal interventions. However, we recommend discussing any protocol with your prescribing practitioner, especially if you're on fertility treatments.
Does this help with perimenopause symptoms?
The microbiome influences how the body processes changing hormone levels. Many people in perimenopause find that gut support helps with symptom management and transition, though individual experiences vary.
Is this appropriate for fertility conditions requiring IVF?
IVF and other fertility treatments should be managed with your reproductive specialist. Many clinics now recognise the microbiome's role and support gut health as a complementary approach.
Ready to support your hormones from your gut?
Start with Gentle Reset — building the microbiome foundation for hormonal balance.
Shop Gentle Reset- Human-origin strains
- 1 trillion CFU per sachet
- 1,450+ reviews, 4.9 stars
- Free shipping over $300
A collection of gut bacteria that directly metabolises your hormones. Gut health is hormone health.